Kamiya:抗酒石酸酸性磷酸酶TRAP 染色試劑盒

       人類及動物體骨組織不斷地進行著重建，骨重建過程包括骨的分解吸收與新骨的形成。破骨細胞（Osteoclast，OC）負責骨分解與吸收，而成骨細胞（osteoblast，OB）負責新骨形成。破骨細胞貼附在舊骨區域，分泌酸性物質溶解礦物質，分泌蛋白酶消化骨基質，形成骨吸收陷窩；其后，成骨細胞移行至被吸收部位，分泌骨基質，骨基質礦化而形成新骨。破骨與成骨過程的平衡是維持正常骨量的關鍵。   

       抗酒石酸酸性磷酸酶（TRAP，tartrate-resistant acid phosphatase）為破骨細胞的標志酶，特異地分布于破骨細胞中，為破骨細胞所特有。通常作為鑒別破骨細胞的重要標志物，使破骨細胞呈紅色。  

TRAP Staining Kit

       艾美捷科技作為專業的生命科學領域解決方案供應商，為您推薦39年老品牌，Kamiya暢銷產品，眾多Nature文章使用認證！

       * 產品僅限用于科研學術研究用途，不得用于醫療與診斷。  

       TRAP Staining Kit，Nature文章結果鑒賞：

       ①【Nature Medicine, IF=87.2】  

TRAP stain: TRAP染色 (osteoclasts (o/c))

        ② 【Nature Biomedical Engineering, IF=29.2】A multi-organ chip with matured tissue niches linked by vascular flow  

TRAP stain: TRAP染色

TRAP Activity: TRAP活性

       【更多發表文章】

      Sherlock, Jonathan P et al. "IL-23 induces spondyloarthropathy by acting on ROR-γt+ CD3+CD4-CD8- entheseal resident T cells". Nature medicinevol.18,7 (2012): 1069-76.

      Ronaldson-Bouchard, Kacey et al. "A multi-organ chip with matured tissue niches linked by vascular flow". Nature biomedical engineering vol.6,4 (2022): 351-371. doi:10.1038/s41551-022-00882-6

      Bae, Sung-Jin et al. "Ninjurin1 positively regulates osteoclast development by enhancing the survival of prefusion osteoclasts". Experimental & molecular medicine vol.51,1 (2019): 1-16.

      Kang, J., Choi, Y.J., Seo, B.Y. et al. A Selective FGFR inhibitor AZD4547 suppresses RANKL/M-CSF/OPG-dependent ostoclastogenesis and breast cancer growth in the metastatic bone microenvironment. Sci Rep 9, 8726 (2019).

      Zhang, Lan, et al. "Adiponectin ameliorates experimental periodontitis in diet-induced obesity mice."PloS one 9.5 (2014): e97824.

      Kang, Moo Rim et al. "Agelasine D suppresses RANKL-induced osteoclastogenesis via down-regulation of c-Fos, NFATc1 and NF-κB". Marine drugs vol.12,11 (2014): 5643-56.

      Sherlock, Jonathan P., et al. "IL-23 induces spondyloarthropathy by acting on ROR-γt+ CD3+ CD4? CD8? entheseal resident T cells."Nature medicine18.7 (2012): 1069-1076.

      Kim, Jinkoo, et al. "Erythropoietin mediated bone formation is regulated by mTOR signaling."Journal of cellular biochemistry113.(2012): 220-228.

      Lee, Yu-Chen, et al. "Src family kinase/abl inhibitor dasatinib suppresses proliferation and enhances differentiation of osteoblasts."Oncogene 29.22 (2010): 3196-3207.

      Lu, Yi et al. "Activation of MCP-1/CCR2 axis promotes prostate cancer growth in bone". Clinical & experimental metastasis vol.26,2 (2009): 161-9. doi:10.1007/s10585-008-9226-7

      Geng, Weidong et al. "Inhibition of osteoclast formation and function by bicarbonate: role of soluble adenylyl cyclase". Journal of cellular physiology vol.220,2 (2009): 332-40.

      Simonaro, Calogera M., et al. "Mechanism of glycosaminoglycan-mediated bone and joint disease: implications for the mucopolysaccharidoses and other connective tissue diseases."The American journal of pathology172.1(2008): 112-122.

       Kamiya Biomedical Company于1983年成立于美國加利福尼亞，1996年公司遷至華盛頓。Kamiya公司旨在為生命科學和醫學界提供高品質的創新的實驗室研究和診斷工具。產品線包括數千種用于臨床前研究的人類和動物生物標志物的檢測，是選擇非常多的ELISA試劑盒供應商之一。Kamiya還提供各種其它生命科學研究產品，包括酶抑制劑和單克隆/多克隆抗體，用于多種領域，包括細胞凋亡、多藥耐藥性、氧化損傷/DNA損傷和修復、骨生物學、癌癥、心臟健康、炎癥、應激、肥胖和糖尿病等。最近，Kamiya推出了新的創新K-ASSAY化學分析儀試劑，用于胰島素、D-二聚體、因子XIII、血漿FDP、血清/尿液FDP和總IgE檢測等。   

       看到這兒，您心動了嗎？馬上聯系Kamiya中國區總代理，艾美捷科技！